Rod photoreceptors are among the most sensitive light detectors in nature. They achieve their remarkable sensitivity across a wide variety of species through a number of essential adaptations: a specialized cellular geometry, a G‐protein cascade with an unusually stable receptor molecule, a low‐noise transduction mechanism, a nearly perfect effector enzyme, and highly evolved mechanisms of feedback control and receptor deactivation. Practically any change in protein expression, enzyme activity, or feedback control can be shown to impair photon detection, either by decreasing (...) sensitivity or signal‐to‐noise ratio, or by reducing temporal resolution. Comparison of mammals to amphibians suggests that rod outer‐segment morphology and the molecules and mechanism of transduction may have evolved together to optimize light sensitivity in darkness, which culminates in the extraordinary ability of these cells to respond to single photons at the ultimate limit of visual perception. (shrink)

Hypocrisy is a multi-faceted concept that has been studied empirically by psychologists and discussed logically by philosophers. In this study, we pose various behavioral scenarios to research participants and ask them to indicate whether the actor in the scenario behaved hypocritically. We assess many of the components that have been considered to be necessary for hypocrisy (e.g., the intent to deceive, self-deception), factors that may or may not be distinguished from hypocrisy (e.g., weakness of will), and factors that may moderate (...) hypocrisy (e.g., the degree of discrepancy between the attitude and behavior, whether the attitude is stated publicly, and the nature and severity of the behavioral consequences). Our findings indicate that lay conceptions of hypocrisy are often at odds with philosophical speculation. We argue that a complete understanding of the criteria for hypocrisy requires consideration of how ordinary people construe the concept. In contrast to some concepts (e.g., physical causation), for which lay conceptions, while interesting, are largely irrelevant, hypocrisy is an essential component of social judgment. One could argue, therefore, that folk wisdom is the ultimate arbiter of what hypocrisy entails. We note limitations of our methodology and suggest avenues for future research. (shrink)

We provide a retrospective of 25 years of the International Conference on AI and Law, which was first held in 1987. Fifty papers have been selected from the thirteen conferences and each of them is described in a short subsection individually written by one of the 24 authors. These subsections attempt to place the paper discussed in the context of the development of AI and Law, while often offering some personal reactions and reflections. As a whole, the subsections build into (...) a history of the last quarter century of the field, and provide some insights into where it has come from, where it is now, and where it might go. (shrink)

The last two decades have seen Marxism's academic renascence. In fields as diverse as law, literary criticism, history, and philosophy, Marxism once again captivates no small number of scholars. In part, this reassessment is driven by the efforts of a group of philosophers and economists to reconstruct Marx from the ground up on a more rigorous basis. The work of these "Analytical Marxists" -- who include G.A. Cohen, Jon Elster, and John Roemer -- is given a sustained examination and critique (...) in David Gordon's Resurrecting Marx. The charge of the Analytical Marxists that capitalism is inherently exploitative and unjust is the primary subject of Gordon's book. Gordon takes issue with that contention; he argues that the Analytical Marxists' withering criticism of classical Marxism is essentially correct, but that they fail to replace it with a superior theoretical edifice. Gordon also analyzes the Analytical Marxists' reformulation of the Marxian notion of exploitation, the implications of their rejection of the labor theory of value, their differences over what rights people have, and their arguments for the compatibility of markets with socialism. (shrink)

Robert M. Adams has written a fairly short book, but into it he has packed a lifetime of rigorous analytic thought, and, what is rarer, deep insight into the nature of things. The book expands and recasts Gifford Lectures that Adams delivered in 1999, as well as other lectures and papers, and though it addresses difficult issues, Adams's clear style, retaining the informality of lectures, considerably eases the task of the reader; and the book is not without an occasional touch (...) of humour, e.g. ‘As metaphysicians we may wish to assign a certain oomph to one side or the other in such lawgoverned relations; but it is not clear that the concept of oomph is at home in fundamental physics’ (p. 12).I cannot cover all the many and various topics in the book, but I shall endeavour in what follows to present a central thread of argument in it, the distinction between what is and what is in itself (the centrality of which is indicated by its presence in the book's title) and to show how this distinction leads to the theistic and idealist metaphysics to which the author is inclined. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

Drawing on ten years of research on the unpublished Wittgenstein papers, Stern investigates what motivated Wittgenstein's philosophical writing and casts new light on the Tractatus and Philosophical Investigations. The book is an exposition of Wittgenstein's early conception of the nature of representation and how his later revision and criticism of that work led to a radically different way of looking at mind and language. It also explains how the unpublished manuscripts and typescripts were put together and why they often provide (...) better evidence of the development of his ideas than can be found in his published writing. In doing so, the book traces the development of a number of central themes in Wittgenstein's philosophy, including his conception of philosophical method, the picture theory of meaning, the limits of language, the application of language to experience, his treatment of private language, and what he called the "flow of life." Arguing that Wittgenstein's views are often much more simple (and more radical) than we have been led to believe, Wittgenstein on Mind and Language provides an overview of the development of Wittgenstein's philosophy and brings to light aspects of his philosophy that have been almost universally neglected. (shrink)

The word “picture” occurs pervasively in Wittgenstein's later philosophy. Not only does Wittgenstein often use literal pictures or the notion of mental pictures in his investigations, but he also frequently uses “picture” to speak about a way of conceiving of a matter (e.g. “A picture held us captive” at Philosophical Investigations§115). I argue that “picture” used in this conceptual sense is not a shorthand for an assumption or a set of propositions but is rather an expression of conceptual bedrock on (...) the model of an organising myth. This reading builds primarily on work by Gordon Baker and Stanley Cavell. (shrink)

This chapter examines the developments that led from Wittgenstein’s early logical atomist view that all meaningful discourse can be analyzed into logically independent elementary propositions to his later philosophy. In 1929, Wittgenstein rejected logical atomism for a “logical holist” conception of language as composed of calculi, formal systems characterized by their constitutive rules. By the mid-1930s, he had rejected the model of a calculus, emphasizing that language is action within a social and natural context — more like a game than (...) a calculus — and that rule-governed behavior is dependent on a background of practices which cannot themselves be explicitly formulated as rules. The discussion of these central developments for the emergence of his later “practical holism” focuses on changes in his conception of the nature of measurement and the role of mind and mental processes in linguistic meaning. (shrink)

Unlike most books on Wittgenstein, Wittgenstein on Mind and Language begins from the initial articulation of his thoughts in his first drafts, conversations, and lectures, and attends closely to the process of revision that led to the Tractatus and Philosophical Investigations. This introductory chapter provides information about the nature of the Wittgenstein papers, summarizes the rationale for reading his work in this way, and outlines the reading of the development of Wittgenstein’s philosophy that this approach yields. This discussion on the (...) development of Wittgenstein’s thought emphasizes the role of his changing conception of the nature of experience and its relationship to the world, the closely related problem of the relationship between ordinary language and its analysis, his later conception of the role of analogies in generating — and dissolving — philosophical problems, the parallels with psychoanalysis, and the variety of philosophical methods employed in his later philosophical writing. There is also an overview of a central theme of the book as a whole: the contrast Wittgenstein drew between “ordinary” and “philosophical” ways of looking at things when he wrote the Tractatus, and how that contrast was transformed in his subsequent writing, focusing on his contrast between “primary” and “secondary” worlds and his notion of a “phenomenological language”. (shrink)

An analysis of the sources of Wittgenstein’s picture theory — which include not only his moment of insight on reading a magazine story about the use of models in a traffic court, but also the work of Russell, Hertz, and Boltzmann — provides the basis for an exploration of Wittgenstein’s articulation of a pictorial conception of representation in his wartime notebooks and its crystallization in the Tractatus. A discussion of Wittgenstein’s later criticism of the picture theory and his notion of (...) a “philosophical picture” illustrates the fundamental reversal in his transition to his later conception of philosophy: instead of taking literal pictures as a guide to the nature of meaning, he came to regard philosophical theories as akin to expressing an aesthetic preference for a certain style of representation. Wittgenstein’s treatment of factual language in the picture theory is related to his Tractarian approach to logical form, and the role of the show/say distinction in his early conception of logic and language. Particular attention is given to the difficulties generated by the idea that the conditions for the possibility of a given domain of discourse cannot be described in language, but must be shown by the form of words in question. (shrink)

This chapter argues that the ontology of the Tractatus is best understood as the consequence of Wittgenstein’s conception of logic and representation in general, and the postulate of the determinacy of sense in particular. Once it is recognized that Wittgenstein arrived at the idea of simple objects based on an abstract argument about the nature of complexes and analysis without providing any specific examples of such analyses, it is easy to see the need for caution in attributing any characteristics to (...) the objects over and above those demanded by Wittgenstein’s logicolinguistic commitments. Commentators have taken the Tractatus to be setting out a bewildering variety of highly specific views about the nature of objects. But the truth is that the book is so programmatic that its ontology can be elaborated in any number of ways. The final section of this chapter analyzes Wittgenstein’s treatment of the self in the Tractatus and his writing from the 1930s as a central example of the extreme tensions between the positivisistic doctrines stated in the Tractatus and the antipositivistic subtext it aims to convey or “show”: if the exoteric doctrine of the Tractatus is that there is no such thing as the subject of experience, the esoteric doctrine is that there is. This leads to a close reading of his proposal in the early 1930s that is considered a “subjectless” language as a way of clarifying the nature of experience, and his subsequent critique of the notions of the “metaphysical self” and the “visual world”. He had transmuted the difference between the first person and third person modes of speech into differences between two worlds and then had tried to put them back together again. (shrink)

The first section of this chapter presents a close reading of Wittgenstein’s “Remarks on Logical Form”, focusing on the conception of the relationship between language and experience, and the nature of the analysis of immediate experience that are set out there. Section two sets out an interpretation of what Wittgenstein meant when he said that he had rejected “phenomenological language” or “primary language” as his goal. Distinguishing between a weak and a strong sense of these terms shows how he could (...) have given up the goal of formulating a language that would amount to a complete analysis of immediate experience, yet retain the goal of finding ways of clarifying what we say about experience. Section three discusses Wittgenstein’s use of the analogy of the pictures on a roll of film in a movie projector and the pictures on a cinema screen for the relationship between world and experience. The final section analyzes how and why the analogy leads Wittgenstein to a paradoxical conception of immediate experience as a separate realm, “timeless” and “neighborless”, a conception of the “world as idea” that is supposedly inexpressible. (shrink)

In 1929, Wittgenstein made use of river imagery to convey the supposedly inexpressible thesis that all is in flux. However, he rejects this extreme thesis in manuscripts from the early 1930s and drafts of the Philosophical Investigations, affirming that one can step twice into the same river. His later discussion of the “stream of life” involves a return, in certain respects, to the river analogy, albeit in a very different key. Examining Wittgenstein’s changing use of this image casts light on (...) the continuities and discontinuities in the development of his philosophy. Wittgenstein’s argument that a private definition is impossible because ostension always depends on a “technique of use”, and his rejection of a positive theory of mind is clarified by examining some unusually explicit notes for a public lecture on private language. This material shows how the treatment of training and practice in the opening sections of the Philosophical Investigations is the basis for the subsequent discussion of both rule-following and privacy. (shrink)

Analysis of symphonies no. 5, 8, 9 and 3.

Otto Weininger was one of the most controversial and widely read authors of fin-de-siècle Vienna. He was both condemned for his misogyny, self-hatred, anti-semitism and homophobia, as well as praised for his uncompromising and outspoken approach to gender and morality. For Wittgenstein Weininger was a 'remarkable genius'. He repeatedly recommended Weininger's Sex and Character to friends and students and included the author on a short list of figures who had influenced him. The purpose of this new collection of essays is (...) to explore the various ways in which Wittgenstein absorbed and responded to Weininger's ideas. Written by an international team of experts on Wittgenstein and Weininger, the volume is especially timely in the light of recent translations of Weininger's work and will appeal to anyone interested in the history of 20th century philosophy, and the literary and cultural history of fin-de-siècle Vienna. (shrink)

This paper uses a semiotic, performative theory of language and post-colonial theory to argue that nursing's representations of ‘multiculturalism’ need to be grounded in a theory of whiteness, an historicized understanding of how ethnic/cultural differences come to be represented in the ways they are and informed by Foucault's notions of power/knowledge. Using nursing education and ‘cultural compentency’ as examples, the paper draws on a range of literatures to suggest more critical and politically productive ways of approaching difference from within nursing's (...) largely white interpretive framework. (shrink)

We present a new understanding of Christ’s real presence in the Eucharist on the model of Stump’s account of God’s omnipresence and Green and Quan’s account of experiencing God in Scripture. On this understanding, Christ is derivatively, rather than fundamentally, located in the consecrated bread and wine, such that Christ is present to the believer through the consecrated bread and wine, thereby making available to the believer a second-person experience of Christ, where the consecrated bread and wine are the way (...) in which she shares attention with him. The consecrated bread and wine are then, in a sense, icons of Christ. (shrink)

Semiotic objections to markets urge us not to place a good on the market because of the message that doing so would send. Brennan and Jaworski reject them on the grounds that either the contingent semiotics of a market can be changed or the weakness of semiotic reasons allows them to be ignored. The scope of their argument neglects the impure semiotic objections that claim that the message a market sends causes, constitutes, or involves a nonsemiotic wrong. These are the (...) most compelling class of semiotic objections and are the kind actually advanced in the literature. Rather than focusing on the necessity or contingency of a market's semiotics, we should instead attend to a semiotic objection's most important feature: its purity or impurity. (shrink)

In this new introduction to a classic philosophical text, David Stern examines Wittgenstein's Philosophical Investigations. He gives particular attention to both the arguments of the Investigations and the way in which the work is written, and especially to the role of dialogue in the book. While he concentrates on helping the reader to arrive at his or her own interpretation of the primary text, he also provides guidance to the unusually wide range of existing interpretations, and to the reasons (...) why the Investigations have inspired such a diversity of readings. Following closely the text of the Investigations and meant to be read alongside it, this survey is accessible to readers with no previous background in philosophy. It is well-suited to university-level courses on Wittgenstein, but can also be read with profit by students in other disciplines. (shrink)

Philosophical analysis of ecological theories has lagged behind the study of evolutionary theory. The semantic conception of scientific theories, which has been employed successfully in the analysis of evolutionary theory, is adopted here to analyse ecological theory. Two general problems in ecology are discussed. One arises from the continued use of covering law models in ecology, and the other concerns the applicability of ecological theory in conservation biology. The semantic conception of ecological theories is used to resolve these problems.

There are some things money literally cannot buy. Invariably transformable goods are such things because when they are exchanged for money, they become something else. These goods are destroyed rather than transferred in monetary exchanges. They mark out an impassable limit beyond which money and the market cannot reach. They cannot be for sale, in the strongest and most literal sense. Variably transformable goods are similar. They can be destroyed when offered or exchanged for money, but they differ in their (...) ability to sometimes emerge from financial transactions intact. -/- Analyzing transformable goods reveals informative and surprising results. Like other goods and commodities, they are agent relative, defined by the way particular agents value them. Inside the same transaction, a good could be transformable for one agent and not another, depending on how and what these agents value in the transaction. Applying this conceptual framework can reveal otherwise obscure facets of existing and future debates about the ethics and limits of markets. To demonstrate this, the framework is here applied to Richard Titmuss’s arguments about markets in blood, clarifying and illuminating some of his most confusing claims. Applying this framework to other debates may reveal even more striking results. (shrink)

Identity, Morality, and Threat offers a critical examination of the social psychological processes that generate outgroup devaluation and ingroup glorification as the source of conflict. Daniel Rothbart and Karyna Korostelina bring together essays analyzing the causal relationship between escalating violence and opposing images of the Self and Other.

Understanding biological systems in terms of scientific materialism has arguably reached a frontier, leaving fundamental questions about their complexity unanswered. In 1998, Friedrich Cramer proposed a general resonance theory as a way forward. His theory builds on the extension of the quantum physical duality of matter and wave to the macroscopic world. According to Cramer’ theory, agents constituting biological systems oscillate, akin to musical soundwaves, at specific eigenfrequencies. Biological system dynamics can be described as “Symphonies of Life” emerging from the (...) resonance (and dissonance) of eigenfrequencies within the interacting collective. His theory has potential for studying biological problems of increasing complexity in a fast‐changing Anthropocene from a new and transdisciplinary angle. Despite data becoming increasingly available for analyses, Cramer's theory remains ignored and therefore untested a quarter century after its publication. This paper discusses how the theory can move to quantitative assessments and application. Cramer's general resonance theory deserves revival. (shrink)